Resultados: 19

Economic evaluation of antipsychotics for the treatment of schizophrenia: a systematic review

Objective: The aim of this study is to conduct a systematic review on cost-effectiveness analysis of oral antipsychotic agents to identify the trend of cost-effectiveness of drugs available for the treatment of schizophrenia. Methods: A search was conducted in three databases (MEDLINE, LILACS and PsycINF...

Cost-effectiveness of dengue vaccination in Brazil

Objective: To define the economic value of a tetravalent dengue vaccine in Brazil by estimating the cost-effectiveness vaccine price threshold per dose. Methods: A dengue dynamic transmission model was used to estimate the public health impact of dengue vaccination and related economic parameters. Two va...

Cost-minimization and budget impact analysis of certolizumab pegol for patients with Crohn’s disease, moderate or severe, with relapse after conventional treatment from the perspective of the Brazilian private payer

Objectives: Budget impact and cost-effectiveness analysis are often required by payers when discussing drug reimbursement. We hereby present a cost-minimization (CMA) and budget impact analysis (BIA) regarding the incorporation of certolizumab pegol (CZP) for the treatment of patients with Crohn’s dise...

Hospitalization of schizophrenic patients in the public health system of Minas Gerais, Brazil

Objectives: The aim of this study was to describe the socio-demographic and clinical variables, identify the determinants of length of stay and estimate the cost of inpatient treatment of schizophrenia in Minas Gerais, Brazil. Methods: A non-concurrent cohort was conducted in three psychiatric hospitals ...

Cost-effectiveness of atypical antipsychotics for the treatment of schizophrenia

Objectives: To conduct a cost-effectiveness analysis of second-generation antipsychotics (SGA) for schizophrenia in Brazil. Methods: A Markov model was built for the evaluation of the cost-effectiveness of risperidone, quetiapine, ziprasidone and olanzapine in the Brazilian public health system. The time...

Health-related quality of life in elderly: a review of the EQ-5D use

Objective: To systematically identify and review studies that used EQ-5D to assess health-related quality of life (QoL) in elderly. Methods: Relevant literature was searched in MEDLINE and Lilacs databases and the EuroQol Plenary Meetings Proceedings (June/2003 to June/2013). The inclusion criteria were ...

Estimation of the potential impact of dengue vaccination on clinical outcomes in Brazil

Objective: The aim of the current analysis was to measure the public health impact of dengue vaccination in Brazil using a published transmission dynamics model. Methods: We adapted a mathematical model that represented the transmission dynamics of the four dengue fever serotypes in humans and in the mos...

Net present value as an instrument to simplificate the decision making process in health technologies economic evaluation

Objectives: The study aims to highlight the Present Value (PV) as a financial analysis tool which could simplify the decision making process of introducing health technologies. The financial evaluation can be extended as necessary, including outcomes and utility. As a model, the instrument was applied to...

Sequential biological therapies in metastatic colorectal cancer (mCRC): a cost comparison analysis for wildtype RAS mCRC patients in Brazil

Objective: To compare the treatment costs of different sequences of regimens including monoclonal antibodies in metastatic colorectal cancer (CRCm) treatment for the Brazilian Supplementary Healthcare System. Methods:  Sixteen scenarios were analyzed, each one comparing a sequence of bevacizumab TML plu...

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